IRF7 and Zika virus infectious disease: Adult mouse models of ZIKV infection are usually performed after blocking or attenuating IFN α/β signaling [10,38,39], as is the case with mice lacking the interferon receptor lfnar1−/− and triple knockout (TKo) mice for type I interferon regulatory factors, such as Irf3−/− Irf5−/− Irf7−/− Irf7−/−.