At 72 h post-infection, RT-qPCR, WB, and plaque assay showed that when TRIF, MAVS, and STING in IPEC cells were silenced by corresponding siRNA, N gene transcription, N protein expression, and virus replication levels of PEDV were slightly increased compared with the control group (Figure 7D–F and Figure S3). Here, MAVS is linked to infection.