TNF and neoplasm: Finally, the plasticity of immune cells contributes to the formation process of new vessels in the tumor environment (angiogenesis), the production of factors such as VEGFA, EGF, FGF2, IL-8, CXCL12, TNFα, IL-1β, VEGF, TGFα, HGF, ANG1, CXCL1, CXCL8, CXCL9, CXCL10, CCL3, IL-10, Arg1, and galectin-1, stimulate this event [89].