The pronounced elevation of TNF-alpha, IL-17, IL-23, IL-22, and IL-1 β promotes an overall systemic chronic subclinical inflammation, which, along with shared genetic features, explains the association between psoriasis and other comorbid conditions, namely psoriatic arthritis (PsA), cardiovascular disease, metabolic syndrome, psychiatric disorders, malignancy, as well as inflammatory bowel disease (IBD) [2]. This evidence concerns the gene IL37 and psoriasis.