On the other hand, there are several non-coding RNAs comprising both microRNAs and long-noncoding RNAs that potentiate or inhibit the progression of CKD; among those is mir-34a, which activates renal fibrosis via downregulating klotho (an endogenous inhibitory of the fibrosis) and induces renal tubular epithelial-to-mesenchymal transition, thus provoking renal fibrosis [10]. The gene discussed is KL; the disease is renal fibrosis.