In relation to DRD4-VNTR, the patients carrying one or two DRD4-L variants in DRD4-VNTR had a tendency for a higher risk of obesity BMI than patients carrying two DRD4-S variants In DRD4-VNTR (X2: 3.54, df: 1, p = 0.060, OR: 1.77 [1.01–3.09]). This evidence concerns the gene DRD4 and obesity due to melanocortin 4 receptor deficiency.