IL6 and central nervous system cancer: The use of Arg-Hex as a vector, for instance, for the delivery of AntimiR-221 PNA to U251 glioma cells caused a foreseen increase in apoptosis [83], while the transfection of premiR-93 was successfully associated with the significant inhibition of IL-8 and IL-6 mRNAs and a related decrease in IL-8 and IL-6 release [82].