The in vivo localization of this dendrimer 1c-G5 after injection into the tumor of rats bearing intracerebral implants of F98 wild-type (F98WT) receptor (−) or EGFR gene-transfected F98EGFR glioma cells demonstrated a much larger localization in F98EGFR versus in F98WT gliomas [59]. Here, EGFR is linked to central nervous system cancer.