Given that SHED stem cells, when cultured in vitro with trophic factors such as EGF and bFGF, express proneural genes (Ngn2 and Mash1) or dopaminergic neuron-like markers (dSHED) by BDNF (brain-derived neurotrophic factor), treatment could promote beneficial effects in Parkinson’s. This evidence concerns the gene BDNF and Parkinson disease.