TP53 and cancer: Another ACP, which consisted of PNC-28 (a peptide derived from the MDM-2-binding domain of p53) conjugated to penetratin (RQIKIWFQNRRMKWKK) via its carboxyl terminal end, blocked pancreatic cancer cell growth in vivo and induced tumor cell necrosis expression in 13 different human cancer cell lines without affecting normal cells (i.e., pancreatic acinar cells, breast epithelial cells, and human stem cells) [99,100].