TNFSF10 and familial pancreatic carcinoma: To improve TRAIL antitumor and cytocidal effects against pancreatic cancer cells, the 114–121 amino acid coding sequence “VRERGPQR” of TRAIL was substituted with the amino acid sequence “RRRRRRRR” to create the novel mutant TRAIL protein TRAIL-Mu3, which induced pancreatic cancer cell death more efficiently than TRAIL by up-regulating DR5 and activating caspase [104].