In one such study, a novel mutant protein TRAIL-Mu3 was synthesized by replacing the TRAIL 114–121 amino acid sequence “VRERGPQR” with the CPP sequence “RRRRRRRR.” The results of the study indicated that addition of TRAIL-Mu3 to pancreatic cancer cells resulted in penetration of the cell plasma membrane by TRAIL-Mu3, which resulted in more extensive pancreatic cancer cell death than that induced by wild-type TRAIL. Here, TNFSF10 is linked to familial pancreatic carcinoma.