TNFSF10 and exocrine pancreatic carcinoma: Furthermore, the TRAIL mutant R6 (MuR6-TR) exerted a greater inhibitory effect on tumor growth than did natural TRAIL when used to inhibit activities of pancreatic carcinoma cell lines BxPC-3 and PANC-1, thus indicating that the CPP sequence may have enhanced the ability of TRAIL-Mu3 to penetrate the cell membrane without increasing cell sensitivity to TRAIL [140].