A meta-analysis of the comparative efficacy of antidepressants on peripheral BDNF concentrations in patients with depressive disorder revealed that both SSRIs and serotonin and norepinephrine reuptake inhibitors (SNRIs) boosted BDNF levels after a period of treatment, and sertraline outperformed the other three medications (venlafaxine, paroxetine, or escitalopram) in terms of early BDNF concentration rise [70]. The gene discussed is BDNF; the disease is depressive disorder.