Another recent study explored the role of the antioxidant hesperetin in a reserpine-induced depression model in male rats, revealing that this compound, found in citrus peels, could significantly improve BDNF levels in the hippocampus of these animals and decrease oxidative stress levels by increasing antioxidative markers, particularly superoxide dismutase and glutathione peroxidase [75]. This evidence concerns the gene BDNF and major depressive disorder.