GSTM1 and neoplasm: The above results could indicate that ZIF-8 is an excellent MOF nanomaterial that can avoid the destruction of OHZ nanoparticles in the lysosome but can decompose in the microenvironment of a tumor to release Hb to generate large amounts of O2, alleviating tumor hypoxia while providing a rich source of O2 for US-induced ROS generation.