DEX-expressing AFP can promote antigen-specific immune response, suppress tumor growth, and alter the TME by increasing the expression levels of IFN-γ, interleukin-2 (IL-2), and CD8+ T lymphocyte, as well as decreasing the levels of regulatory T cells (Treg), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β) [99]. This evidence concerns the gene CD8A and neoplasm.