Mutations in GBA, LRRK2 and VPS35 are linked to dysfunction in the autophagy–lysosomal pathway (ALP) and they induce AD PD, whereas mutations in PRKN, PINK1 and DJ-1 are associated with mitochondrial pathways and cause autosomal recessive (AR) PD [66,67]. Here, PRKN is linked to Parkinson disease.