Rotenone, an insecticide with neurotoxic effects similar to those observed in PD, has been reported to decrease HSP27 (striatum and substantia nigra), HSP90 (cerebellum, cortex, substantia nigra, and striatum) and HSP70 (cortex and substantia nigra) expression, while it induced an increase of HSP60 expression in the striatum, cerebellum, cortex, and substantia nigra after administration for 11 days to rats [137]. This evidence concerns the gene HSPB2 and Parkinson disease.