HAO1 and neoplasm: An excellent method to decrease the pH and increase the H2O2 level in the tumor microenvironment (TME) is to include glucose oxidase (GOx) in the CDT cargo because GOx catalyzes, using the co-factor Flavine Adenine Dinucleotide (FAD), the oxidation of β-D-glucose to H2O2 and D-glucoco-1,5-lactone that further hydrolyzes to gluconic acid (vide infra).