ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: As the IL-3 receptor is overexpressed in chronic myelogenous leukemia (CML) and acute myeloid leukemia blasts [98,99], exosomes derived from these cells loaded with imatinib or BCR-ABL siRNA effectively target and inhibit the growth of CML cells both in vitro and in vivo.