VCP and neoplasm: Having shown that intravenous injection of LPNP-p198 inhibited tumor growth in an orthotopic PDAC mouse model through VCP-downregulation-mediated sensitization to gemcitabine treatment, we sought to further delve into the clinical relevance of LPNP-mediated therapy by conducting a safety profile of liver- and kidney-function-related parameters following LPNP-p198 treatment at the efficacious dosing regimen tested.