Indeed, NtB of 4 μL of lactated Ringer’s solution containing 1% bovine serum albumin and 500,000 cpm/μL of radioactively labeled iodinated PACAP (I-PACAP) in presence or absence of 5% β-cyclodextrin, (2-Hydroxypropyl)-β-cyclodextrin or α-Cyclodextrin was administrated to aged SAMP8 mice, an animal model of Alzheimer’s disease. The gene discussed is ADCYAP1; the disease is early-onset autosomal dominant Alzheimer disease.