STING1 and melanoma: In a recent study conducted using the B16F10 murine melanoma model, Chelvanambi et al. reported that a low dose of the stimulator of interferon gene (STING) agonist ADU S-100 induced TVN and subsequently increased the infiltration of CD8+ T cells and CD11c+ DCs, converting the immunological “cold” TME into a “hot” TME [68].