SF3B1 and B-cell chronic lymphocytic leukemia: Indeed, 1103 genes, including pseudogenes, were upregulated, and 184 genes and pseudogenes were downregulated after treatment with ancistrocladinium A. The enriched proteins include various splicing factors like SRSF1, which had previously been shown to be an essential driver for MM [17] or SF3B1, where it was proven in chronic lymphatic leukemia (CLL) that mutations in the protein directly affect the DNA damage response [29].