Indeed, 1103 genes, including pseudogenes, were upregulated, and 184 genes and pseudogenes were downregulated after treatment with ancistrocladinium A. The enriched proteins include various splicing factors like SRSF1, which had previously been shown to be an essential driver for MM [17] or SF3B1, where it was proven in chronic lymphatic leukemia (CLL) that mutations in the protein directly affect the DNA damage response [29]. The gene discussed is SRSF1; the disease is B-cell chronic lymphocytic leukemia.