ESR1 and neoplasm: At the same time, amino derivatives 26c and 64a,d have a significant effect on the signaling pathways of the estrogen receptor ERα, which supports the growth of hormone-dependent tumor cells MCF-7 and can be considered as double blockers of HIF-1α/ERα, modulating the activity of the HIF-1α and ERK1/2 signaling pathways.