The anti-inflammatory properties of honey on proinflammatory cells and agents by the modulation and reduction of TNF, NF-kB pathways, PI3K/Akt, MAPK, T-Lymphocyte, B-Lymphocyte, RAS, and apoptosis signaling pathways could lead to a prevention of COVID-19 penetration and reproduction in host cells [74]. The gene discussed is TNF; the disease is COVID-19.