For example, withanolide extracted from the leaves of W. somnifera have been reported to inhibit both inducible and constitutive NF-κB activation, thus being involved in blocking the NF-κB activation pathway and NF-κB-regulated gene products that control inflammation, tumor cell survival, invasion, osteoclastogenesis, and potentiating apoptotic cell death in cancerous cell lines [165]. Here, NFKB1 is linked to neoplasm.