As another eIF4E inhibitor, N-7 benzyl guanosine monophosphate tryptamine phosphonamidite prodrug (4Ei-1) upregulates gemcitabine chemosensitivity in lung and breast cancers by inhibiting the mRNA cap-binding ability of eIF4E and degrading the eIF4E protease [169]. The gene discussed is EIF4E; the disease is breast cancer.