The dynamic balance of histone acetylation in the distal promoter region of the PEPT1 gene is maintained by HDAC1, which is responsible for the deacetylation of histone H3 lysine 18 acetylation (H3K18Ac) and H3K27Ac, and P300, which is responsible for catalyzing H3K18Ac and H3K27Ac to enhance the sensitivity of CRC to anticancer drugs [72,73]. Here, SLC15A1 is linked to colorectal carcinoma.