MYC and malignant colon neoplasm: Platycodon saponin, one of the active antitumor components in the Chinese medicine Platycodon, inhibits colon cancer cell growth by downregulating the expression of CCND1, c-Myc, and CDK6, blocking cells in the G1 phase, by inducing apoptosis by shear activation of pro-CASP3 and PARP, and by inhibiting JNK, p38 activation, and ERK1/2 dephosphorylation [116].