After three weeks, mTOR phosphorylation was inhibited and HIF1α expression was downregulated in the tumor, blocking the endothelial mTOR/HIF-1α pathway and creating a microenvironment in which the tumor vasculature is not easily generated, triggering the apoptosis of vascular endothelial cells and inhibiting neoplastic tumor and vessel formation [47]. Here, HIF1A is linked to neoplasm.