For example, the Salvia officinalis extract dihydrotanshinone could inhibit colon cancer cell proliferation by downregulating the expression of β-catenin and/or c-Myc, both of which are proteins downstream of the HDAC1/HIF1α/VEGFA signaling pathway, to inhibit Wnt/β-catenin signaling [100]. This evidence concerns the gene MYC and colonic neoplasm.