CASP3 and colonic neoplasm: Di Guida et al. [95] reported antitumor effects against colon cancer cells (compared to the untreated cell, reducing 60% of colon cancer cell viabilities at 600 μg/mL after 72 h and with a nontoxic lower cell viability reduction (20%), when compared to the untreated control cells, at 200 μg/mL, after 72 h) by a capsular polysaccharide made up of N-acetylated aminosugars, isolated from P. nigrifaciens Sq02-RifT and obtained within a fish gut, which activates Caspases-3 and -9 on the CaCo-2 and HCT-116 of the cancer cells and induces apoptosis.