However, in the early stages of scleroderma Th1 cells and Th17 cells are suggested to dominate the immune profile [74], later shifting to Th2 [75] and this may explain why patients with SSc are characterized by the overexpression of IFNα at the early stages of the disease, which than translates to the disease’s development [76,77]. Here, IFNA1 is linked to systemic sclerosis.