On the other hand, quinidine did not show efficacy in six patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) due to KCNT1 mutations in a single-center, inpatient, order-randomized, blinded, placebo-controlled, crossover trial [125]. This evidence concerns the gene KCNT1 and autosomal dominant nocturnal frontal lobe epilepsy.