MAPK8 and Cerebral ischemia: Considering the role of JNK in cerebral ischemia–reperfusion injury [17,18,19,20,21,22] and data regarding the neuroprotective activity of other JNK inhibitors [22,24,28,31,32,66,69,71], we assume that JNK inhibition is one of the leading mechanisms of TRYP-Ox’s neuroprotective activity.