In the context of our study, of particular interest are the data that some antioxidants (e.g., edaravone, N-acetylcysteine, and tetrahydroxystilbene glucoside) that protect nerve cells from cerebral ischemia–reperfusion injury can also regulate the JNK signaling pathway [21,86,90]. This evidence concerns the gene MAPK8 and brain ischemia.