TF and neoplasm: Firstly, the HeLa tumor spheroid results (Figure 5) indicated that both ACAT-Se-PLGA-NPs and Tf-ACAT-Se-PLGA-NPs inhibit spheroid growth after 12 days of treatment, at 20 and 40 μg/mL, in comparison to free ACAT-Se and control spheroids (p < 0.05).