For the first time, this study demonstrated the expression of different genes in distinct genotypes of the BsmI SNP of the VDR gene (in addition to the VDR itself) in patients with hypovitaminosis D. The BsmI SNP negatively regulated the VDR and SOD2 gene and upregulated CYP24A1, thus showing the modulatory influence of BsmI on other genes in hypovitaminosis D. The gene discussed is VDR; the disease is rickets.