H. pylori represents a major causative factor of peptic ulcer disease, an important precursor lesion of gastric cancer, and possesses virulence factors such as cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A, as well as various outer membrane proteins which have been directly linked to the activation of pathways involved in aberrant cell proliferation and gastric carcinogenesis [16,17]. Here, S100A8 is linked to gastric cancer.