CH is associated with over 12 different genetic loci and the most frequent are inactivating mutations of ABCC8 and KCNJ11 [32], which encode SUR1 and KIR6.2 subunits, with a consequent lack of channels on the beta-cell membrane or channels impaired function and dysregulated insulin secretion [33,34]. This evidence concerns the gene INS and cyclic hematopoiesis.