IH spore powder affects the intestinal microbiota and serum metabolites in B6/JGpt-Apcem1Cin(min)/Gpt (ApcMin/+) mice, a model of colorectal cancer, which in turn affects the JAK/STAT signaling and regulates the abundance of CD8+ T cells to suppress the development of colorectal cancer (CRC) [18]. The gene discussed is SOAT1; the disease is colorectal cancer.