Taken together with the outcomes from Figure 2, the observed higher fat mass in the female patient group compared with the control group and the absence of a correlation between the BFR and nutritional status in the low-IL-16 subgroup of sarcopenic, obese females, we hypothesize that in women with sarcopenia, an elevated IL-16 level may impede the conversion of nutrients into muscle mass and favor a greater direct conversion of nutrients into fat for storage. The gene discussed is IL16; the disease is sarcopenia.