IL16 and obesity due to melanocortin 4 receptor deficiency: Figure 2 demonstrates a consistent pattern in which the females’ BFRs corresponded with the levels of IL-16, with the patient group exhibiting significantly higher values than those in the control group. Fisher’s exact test indicated that female obesity was a risk factor for sarcopenia (OR: 5.83, 95% CI: 1.25, 27.17, p = 0.027), whereas there was no direct association between male obesity and sarcopenia. Based on Table 1, there was no significant difference in nutritional status between the males and females (p = 0.782).