In this study, our investigation successfully identified seven hub genes (IFI44, IFI44L, MX1, OAS3, USP18, IFI27, and ISG15) associated with antiviral activity and the type I interferon response as potential biomarkers for the diagnosis and treatment of COVID-19 in individuals infected with the Omicron variant. This evidence concerns the gene IFI44 and COVID-19.