Additionally, we analyzed a dataset comprising healthy individuals, asymptomatic infected individuals, symptomatic infected individuals, and recovered infected individuals (GSE167930) to identify seven target hub genes (IFI44, IFI44L, MX1, OAS3, USP18, IFI27, and ISG15) that showed correlations with symptom onset and recovery from COVID-19. This evidence concerns the gene ISG15 and COVID-19.