In this study, our investigation successfully identified seven hub genes (IFI44, IFI44L, MX1, OAS3, USP18, IFI27, and ISG15) associated with antiviral activity and the type I interferon response as potential biomarkers for the diagnosis and treatment of COVID-19 in individuals infected with the Omicron variant. The gene discussed is USP18; the disease is COVID-19.