CD8A and neoplasm: In our study, Seq4172 (P. johnsonii) showed an inverse association with changes in BMI in the GNSH cohort during the 3-year follow-up when adjusting for age, gender, and initial BMI, while the latest study [31], an animal experiment, has shown that P. johnsonii can induce the growth of CD8 T cells, which produce interferon-γ and strengthen the anti-tumor immune response.