Other members of the nuclear receptor family, including the pregnane X receptor/steroid and xenobiotic-sensing receptor (PXR/SXR, NR1I2), constitutive androstane receptor (CAR, NR1I3), and the vitamin D3 receptor (VDR, NR1I1), also play a role in transducing the impact on NAFLD caused by bile acids and gut microbiota. The gene discussed is NR1I3; the disease is metabolic dysfunction-associated steatotic liver disease.