On one side, F. nucleatum has been extensively detected in CRCs [34,35], breast [36], lung [37] and other tumor tissues, with its higher abundance in cancerous tissue associated with chemotherapy failure and poor prognosis in CRC [38,39], and an experiment on Apc−/+ mice suggested its presence linked to CRC tumorigenesis [40] through activation of the β-catenin pathway via FadA adhesin binding to E-cadherin on host cells [41]. Here, CDH1 is linked to colorectal carcinoma.