Importantly, these recent humanized transgenic mice developed human NK cells that inhibited HIV-1 replication [84] and utilized antibody-dependent cellular toxicity (ADCC) via a broadly neutralizing antibody PGT121 to suppress infection [97] or CD4-induced antibodies and CD4 mimetic to control viral rebound from the reservoir [97,110] (Figure 1). This evidence concerns the gene CD4 and infection.