There are several reasons to explain the possibility that COVID-19 colonizes the uteroplacental system; first of all, as already mentioned, the large abundance at the placental level, in the syncytiotrophoblast, in the cytotrophoblast, in the endothelium, in the vascular smooth muscle of the primary and secondary villi of ACE2 [27,28], as well as in conditions unrelated to pregnancy, is also expressed in the ovary, uterus, and vagina [29]. The gene discussed is ACE2; the disease is COVID-19.