For instance, CFS derived from Lactobacillus rhamnosus GG was found to prevent CRC cell invasion via reduction of matrix metalloproteinase-9 (MMP-9) expression and increased tight junction protein zona occludens-1 (ZO-1) and tissue inhibitor of metalloproteinase (TIMP) levels [130,131], whereas it exhibits synergistic action with 5-FU [136]. The gene discussed is MMP9; the disease is colorectal carcinoma.