EPSs from Lactobacillus acidophilus 10307 can inhibit the expression of genes involved in tumor angiogenesis and survival, including vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α), while they up-regulate antiangiogenic gene expression, such as tissue inhibitor of metalloproteinase-3 (TIMP-3) [171]. The gene discussed is TIMP3; the disease is neoplasm.