CDH1 and breast carcinoma: Similarly, a recent investigation by Huang et al. (2017) found that HSN with an IC50 value of 62.82 μM/L restricts hypoxia-mediated migration and invasion in human breast cancer MCF-7 cells, most likely through down-regulation of the protein levels of HIF-1α, MMP-9, and Snail and up-regulation of the protein level of E-cadherin [24].