GPT and Hepatic fibrosis: In aged mice with a moderate NAFLD-like phenotype, NRS (2.5 g/kg food for three months) significantly reduced the levels of total cholesterol (TC), TG, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) and increased the amount of liver NAD+, diminished inflammatory infiltration, and mitigated HS and liver fibrosis (LF) [99,100,101].