In experimental models of mouse sepsis induced by lipopolysaccharide (LPS) injection, feces injection in peritoneum, or by cecal ligation and puncture, NR inhibited plasma high mobility group box 1 (HMGB1) release, OXS, and tissue infiltration, increased endogenous antioxidant ability, prevented lung and heart injury, and improved survival [37,41]. This evidence concerns the gene HMGB1 and Sepsis.