STAT3 and cystic fibrosis: In terms of indicators of CF proliferation, Western Blot showed a remarkable increase in STAT3 phosphorylation treatment with ISO (10 μmol L−1), while a significant decrease with pretreatment with ZB (1 μmol L−1) (Figure 6b,d), suggesting that ZB reduced ISO-induced cardiac fibroblast proliferation by the STAT3 signaling pathway.