In this sense, Zhu et al. [31] suggested that bioactive compounds such as 3H-1,2-Dithiole-3-thione can reduce the pro-inflammatory signaling via NF-κB in macrophages cultured under standard conditions and low inflammation (10 ng/mL of LPS) by mitigating the oxidative stress; however, these effects have not been reported under hyperglycemia conditions. Here, NFKB1 is linked to Hyperglycemia.