UHRF1 expression is significantly inhibited by treatment with repurposed chemotherapeutic drugs, such as mithramycin (a DNA-binding antitumor antibiotic produced by the bacterium Streptomyces plicatus), in MPM cells, suggesting UHRF1 as a druggable target in mesotheliomas [167]. The gene discussed is UHRF1; the disease is mesothelioma.