According to the current literature, rare variants have been reported in few studies, significantly associated with SLD; a translocation breakpoint at 15q21 in the CCPG1 (previously called DYX1C1) gene was reported as the first gene to be implicated in dyslexia [51], further to other large deletions/insertions at chromosome 15 that were found [52]. The gene discussed is DNAAF4; the disease is dyslexia.