Among 42 combined TTR (with a follow-up >24 months), only 2 cases of degenerative changes were reported: specifically, in the work by Morita et al., 1 case of osteosclerosis at the talonavicular joint was reported, while 1 out of 3 patients described by West and colleagues presented loosening of the tibial component [29,37]. This evidence concerns the gene TTR and osteosclerosis.